What is Anti-CCP?
Anti-cyclic citrullinated peptide, abbreviated as anti-CCP, is an autoantibody of significance in rheumatology, particularly in the diagnosis of rheumatoid arthritis (RA), also known as rheumatoid joint inflammation. Autoantibodies are proteins in the body that, for some reason, begin to attack the body's own tissues, which can lead to autoimmune diseases.
What makes Anti-CCP particularly interesting is its specific association with RA. It is a more specific test than the more commonly used rheumatoid factor (RF) when it comes to diagnosing RA. Anti-CCP is most commonly found in cases of RA, making it a highly specific marker for this disease.
The analysis of Anti-CCP is performed on blood serum, the clear fluid layer that remains after blood has coagulated and blood cells and certain proteins have been removed. The results of the analysis can help doctors confirm the diagnosis of RA or monitor disease activity in individuals who have already been diagnosed.
Why is Anti-CCP Analyzed?
Anti-cyclic citrullinated peptide is analyzed to facilitate the diagnosis of rheumatoid arthritis or to monitor its progression. Anti-CCP is an important biomarker that contributes to health data for planning and adjusting treatment for individuals with RA. Rheumatoid arthritis is an autoimmune disease that primarily affects the joints and can cause pain, swelling, and joint deformities. The presence of Anti-CCP in the blood is a specific marker for RA, and if the Anti-CCP test is positive, it can strongly support the diagnosis of RA. At the same time, an analysis can help rule out other diseases that may have similar symptoms, such as osteoarthritis or lupus.
What Does an Elevated Anti-CCP Value Mean?
An elevated value provides a strong indication of rheumatoid arthritis (RA), but elevated values can occur in other situations and diseases. It is important to note that a high level of CCP antibodies in itself is not a definitive diagnosis of RA and should be interpreted in conjunction with other clinical factors and by treating physicians.
What is the Reference Range for Anti-CCP?
The reference range can vary slightly depending on the laboratory and the test method used. Additionally, there may be variations based on age, gender, and population group. Therefore, it is important to interpret the results in consideration of the reference intervals provided by the specific laboratory conducting the test.
In general, the value is very low or absent in healthy individuals who do not have rheumatoid arthritis or other related autoimmune diseases. If the Anti-CCP test shows high values, it is highly likely to indicate an increased risk for or presence of RA.
