What is ALP, alkaline phosphatases?
Alkaline phosphatase (ALP) is an enzyme found in several organs, including the small intestine, kidneys, bile ducts, osteoblasts in the skeleton and in the placenta. In adults, the activity in plasma mainly originates from the bile ducts.
Why are ALP, alkaline phosphatases analyzed?
ALP is one of several markers used in monitoring liver values. It is mainly used to investigate liver cell damage and follow-up of liver disease. In various bone diseases, greatly elevated values can be seen.
What can a high value of ALP mean?
High levels of ALP are seen in bone-related diseases such as osteitis deformans, rickets and metastases, hyperparathyroidism and biliary obstruction. ALP levels also rise in late pregnancy due to the addition of placental phosphatase.
What can a low value of ALP mean?
High levels of alkaline phosphatase (ALP) may indicate a disease or hereditary condition such as hypophosphatasia. But it is important to remember that there are several factors that can affect the levels of ALP and that a low level is not always a cause for concern.
