Highly Sensitive S-Estradiol Analysis
An advanced blood analysis performed using mass spectrometry, enabling precise measurement of low estradiol levels below 80 pmol/L. This analysis is recommended only in suspected cases of lower estradiol concentrations and is particularly relevant for men, where standard analyses often lack sufficient precision. Important information: the analysis is performed exclusively at Karolinska University Laboratory, and blood sampling can only be conducted at Karolinska's designated testing units.
Applications of Highly Sensitive Estradiol Analysis
The highly sensitive estradiol test is particularly useful in situations where specific results are required for low estradiol levels. Common conditions or evaluations where this test is recommended include:
- Suspected pubertal disorders such as pubertas praecox or pubertas tarda to assess hormonal development in children and adolescents.
- Diagnosis and monitoring of estrogen-producing tumors in both men and women.
- Evaluation of amenorrhea (absence of menstruation) in cases of suspected hormonal imbalances.
- Downregulation of estradiol prior to IVF treatment to ensure optimal hormonal balance.
- Evaluation of gynecomastia and other hyperestrogenic conditions in men.
Highly Sensitive Estradiol Analysis for Men
Men typically have significantly lower estradiol levels than women, making the highly sensitive estradiol analysis particularly important for obtaining accurate results. In men, estradiol is produced in small amounts by the testes, adrenal glands, and fat tissue, and it plays a crucial role in bone health and spermatogenesis. Since men have lower levels, standard estradiol analyses may miss subtle changes. This test is therefore ideal for men suspected of having estrogen-producing tumors or hormonal imbalances affecting estradiol.
Mass Spectrometry for High Precision
The analysis is performed using chromatography (LC) and mass spectrometry, a method that provides high precision and accurate measurement of estradiol levels below 200 pmol/L. This allows the detection of small changes in hormone production that may be difficult to capture with standard methods. For higher estradiol concentrations, results above 300 pmol/L are measured using an automated immunochemical method instead.
