Blood test to analyze paracetamol concentration
Paracetamol is a commonly used pain reliever and fever reducer that effectively treats mild to moderate pain and fever. However, in cases of overdose, paracetamol can be converted into a toxic metabolite (NAPQI), which may cause severe liver damage. Even with long-term and frequent use of low doses, paracetamol can impact liver function, particularly in individuals with other risk factors such as liver disease or alcohol consumption. A blood test to analyze P-Paracetamol measures the concentration of the drug in the blood and is crucial for assessing the risk of toxic effects, even with chronic use.
P-Paracetamol test
The analysis of P-Paracetamol is based on measuring the drug's concentration in plasma or serum. The blood test is performed using advanced methods such as high-performance liquid chromatography (HPLC) or immunological techniques, ensuring precise and reliable results. This test provides insight into whether the levels are within a safe range or if frequent use may have contributed to liver strain, even at low doses.
Signs of liver impact from long-term use
Long-term daily intake of paracetamol, even within therapeutic limits, may warrant investigation if you:
- Have taken paracetamol regularly over an extended period: Even low doses may gradually affect liver function.
- Experience diffuse symptoms: Such as fatigue, nausea, mild abdominal pain, or decreased appetite, which may be early signs of liver strain.
- Have risk factors: Such as alcohol consumption, liver disease, or the use of other medications that strain the liver.
Gain Insight into your paracetamol levels
- Identify abnormal levels: Even with long-term use at therapeutic doses, this test can provide critical information about potential liver strain.
- Support preventive measures: Regular tests help detect early signs of liver impact before symptoms become severe.
- Prevent complications: The test allows adjustments to medication to reduce the risk of chronic liver damage.
Reference values for P-Paracetamol
Normal levels of P-Paracetamol are below 33 nmol/L. Toxic concentrations typically exceed 300 nmol/L, depending on the time since ingestion. If long-term use is suspected to have an impact, it may also be valuable to measure liver markers such as ALAT, ASAT, and PK-INR for a comprehensive assessment of liver health.